Control | MCI | AD | ||
---|---|---|---|---|
Non-converter | Converter | |||
Sample size | 40 | 38 | 44 | 42 |
Age at baseline FDG-PET | 62.6 ± 11.6 | 72.1 ± 7.60* | 74.7 ± 7.04* | 77.0 ± 7.6* |
Gender (male/female) | 23/17 | 15/23* | 19/25* | 21/21* |
Education (years) | 13.6 ± 3.7 | 6.9 ± 5.0* | 7.1 ± 4.9* | 7.5 ± 5.3* |
APOE Ɛ4 carriers | 23.8% | 37.8%* | 60.9%*§ | 57.9%* |
Baseline MMSE | 28.1 ± 2.1 | 23.5 ± 4.36* | 21.8 ± 3.7* | 17.4 ± 2.9*§# |
Baseline Cognitive ability Screening Instrument | ||||
Total scores (100) | 92.6 ± 6.1 | 77.84 ± 13.9* | 74.9 ± 12.2* | 63.1 ± 15.3*§# |
Long term memory (10) | 9.88 ± 0.7 | 9.2 ± 1.8* | 9.1 ± 2.6* | 7.9 ± 3.6*§# |
Short term memory (12) | 10.5 ± 1.7 | 7.1 ± 3.6* | 4.1 ± 4.0* § | 3.8 ± 1.5*§# |
Attention (8) | 7.3 ± 0.8 | 6.8 ± 1.2* | 6.7 ± 1.4* | 6.5 ± 1.3*§# |
Mental manipulation (10) | 8.8 ± 1.8 | 6.3 ± 2.9* | 7.0 ± 3.2* | 6.3 ± 2.5*§# |
Orientation (18) | 17.7 ± 1.0 | 15.0 ± 4.0* | 11.7 ± 5.1* § | 10.9 ± 2.6*§# |
Drawing (10) | 9.8 ± 0.5 | 8.3 ± 2.3* | 8.1 ± 2.9* | 7.2 ± 3.6*§# |
Abstract thinking (12) | 10.8 ± 1.2 | 8.5 ± 2.3* | 8.3 ± 2.7* | 7.5 ± 2.7*§# |
Verbal fluency (10) | 8.2 ± 2.1 | 5.7 ± 2.3* | 5.8 ± 2.8* | 4.8 ± 1.8*§# |
Language (10) | 9.8 ± 0.8 | 9.0 ± 1.5* | 8.7 ± 2.1* | 4.9 ± 2.1*§# |
Baseline FDG-PET SUVr | ||||
Frontal lobe | 1.41 ± 0.10 | 1.45 ± 0.04 | 1.35 ± 0.06* § | 1.30 ± 0.07*§# |
Medial temporal lobe | 1.10 ± 0.07 | 1.06 ± 0.05 | 0.91 ± 0.07 *§ | 0.86 ± 0.02*§# |
Lateral temporal lobe | 1.40 ± 0.12 | 1.38 ± 0.04 | 1.23 ± 0.08* § | 1.19 ± 0.11*§# |
Posterior cingulate cortex | 1.61 ± 0.13 | 1.60 ± 0.20 | 1.37 ± 0.14 *§ | 1.20 ± 0.07*§# |
Precuneus | 1.61 ± 0.12 | 1.61 ± 0.05 | 1.48 ± 0.09* § | 1.31 ± 0.08*§# |
Parietal lobe | 1.50 ± 0.10 | 1.49 ± 0.04 | 1.36 ± 0.08* § | 1.21 ± 0.06*§# |
Occipital lobe | 1.60 ± 0.11 | 1.59 ± 0.05 | 1.56 ± 0.08 | 1.39 ± 0.12*§# |
Follow-up (years) | 4.4 ± 1.8 | 6.4 ± 3.8* | 6.7 ± 3.6* | 6.6 ± 3.2* |