Fig. 6

FDG-PET topography of the preselected seven volumes-of-interests. The MCI-C group showed prominent hypometabolism in the medial temporal lobe and PCC, and the FDG-PET uptakes over all regions decreased in the baseline and follow-up scans. The difference in the baseline scan became more robust in the follow-up scan. In contrast, the MCI-NC group seemed to have a relatively hypometabolic change in the PCC in the baseline scan; however, this was not noted in the follow-up scan, and there was no significant declining trend over all regions. Numbers on the chart indicate the Z score of FDG-PET. Using Mann-Whitney U test to compare between MCI-C and MCI-NC; * p < 0.05; ** p < 0.01; *** p < 0.001. Abbreviation: MCI-NC, non-converter of mild cognitive impairment; MCI-C, converter of mild cognitive impairment; PCC, posterior cingulate cortex; Med. temporal, medial temporal; Lat. temporal, lateral temporal