Fig. 3

FDG-PET Z score map in a female patient showed conversion in three scans. At the baseline, decreased uptake was noted in the medial temporal lobe and inferior frontal cortex (MMSE = 24; 4 years before dementia). 2.5 years later, hypometabolism was noted in the lateral temporal lobe, posterior cingulate cortex and dorsolateral prefrontal cortex (MMSE = 24; 1.5 years before dementia). Five years after the baseline FDG-PET scan, hypometabolism was more widely spread with a pattern similar to the default mode network (MMSE = 11). Only regions showing a Z score < -2 are displayed. Abbreviations: MMSE, mini-mental state examination